Journal article
Influenza virus infection history shapes antibody responses to influenza vaccination
M Auladell, HVM Phuong, LTQ Mai, YY Tseng, L Carolan, S Wilks, PQ Thai, D Price, NT Duong, NLK Hang, LT Thanh, NTH Thuong, TTK Huong, NTN Diep, VTN Bich, A Khvorov, L Hensen, TN Duong, K Kedzierska, DD Anh Show all
Nature Medicine | NATURE PORTFOLIO | Published : 2022
Abstract
Studies of successive vaccination suggest that immunological memory against past influenza viruses may limit responses to vaccines containing current strains. The impact of memory induced by prior infection is rarely considered and is difficult to ascertain, because infections are often subclinical. This study investigated influenza vaccination among adults from the Ha Nam cohort (Vietnam), who were purposefully selected to include 72 with and 28 without documented influenza A(H3N2) infection during the preceding 9 years (Australian New Zealand Clinical Trials Registry 12621000110886). The primary outcome was the effect of prior influenza A(H3N2) infection on hemagglutinin-inhibiting antibod..
View full abstractGrants
Awarded by University of Melbourne
Funding Acknowledgements
Funding for this study was provided by the National Health and Medical Research Council, Australia (grant 1103367 to A.F.) and National Foundation for Science and Technology Development (NAFOSTED 108.04-2019.08, L.T.Q.M.). The WHO Collaborating Centre for Reference and Research on Influenza is funded by the Australian Government Department of Health. The Oxford University Clinical Research Unit - Hanoi and H.R.v.D. are funded through Wellcome Africa Asia program grants (089276/Z/09/Z and 106680/Z/14/Z). We are grateful to the Ha Nam Preventive Medicine Centre and People's Committees of Thanh Liem District for their support and the people of Thanh Ha Commune for participating in this study. We would like to thank the Thanh Ha Commune health workers for their dedication to conducting active surveillance and cross-sectional surveys. We also wish to thank the Ministry of Health of Vietnam for their continuing support of the research collaboration between the Oxford University Clinical Research Unit and the National Institute for Hygiene and Epidemiology. We are grateful to members of the Oxford University Clinical Research Unit, including P. Horby for his role in establishing the Ha Nam cohort, N. Nguyen Minh Trang for project coordination and B. Huyen Trang for administrative support. A. Malet, H. Peck and Y.-M. Deng and their staff at Melbourne WHO Collaborating Centre for Reference and Research performed initial isolation and characterization of many of the influenza viruses used. We thank S. Sanchez for assisting with microneutralization assays. Thanks also to K. Subbarao and N. Thi Hoang Oanh for helpful comments on the manuscript. K.K. was supported by the Australian National Health and Medical Research Council (Leadership Investigator Fellowship 1173871). M.A. and L.H. were supported by the Melbourne International Research Scholarship and the Melbourne International Fee Remission Scholarship from the University of Melbourne. The funders had no role in the conduct of the study.